The Binding of Isaac: Antibirth Wiki
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Unlockables are new content for the game such as items, characters, or challenges that must be unlocked. They pop up when something has been completed or achieved.


Name Image Description Unlock In Game Secret Number
Bethany
Bethany
You unlocked Bethany Have any combination of 12 soul, black, or immortal hearts during a run 179
Jacob & Esau
Jacob & Esau
You unlocked Jacob & Esau. Defeat The Witness 180
Planetarium
Planetarium
The stars are calling... Acquire three astrology-related items in one run. 181
A Secret Exit
A Secret Exit
Your fate diverges Defeat the three new bosses found on normal floors (Baby Plum, Reap Creep, and The Pile), then die or complete a run. 182
Alabaster Box
Alabaster Box
Alabaster Box has appeared in the basement Defeat The Lamb as Bethany. 183
Book Of Virtues
Book Of Virtues
The Book of Virtues has appeared in the basement Defeat Isaac as Bethany. 184
Blessed Penny
Blessed Penny
The Blessed Penny has appeared in the basement Defeat ??? as Bethany. 185
Beth's Faith
Beth's Faith
Beth's Faith has appeared in the basement Beat Boss Rush as Bethany. 186
Urn Of Souls
Urn Of Souls
Urn Of Souls has appeared in the basement Defeat Satan as Bethany. 187
Rock Bottom
Rock Bottom
Rock Bottom has appeared in the basement Beat Boss Rush as Jacob & Esau. 188
Damocles
Damocles
Damocles has appeared in the basement Defeat The Lamb as Jacob & Esau. 189
Jacob's Ladder
Jacob's Ladder
Jacob's Ladder has appeared in the basement Defeat Isaac as Jacob & Esau. 190
Birthright
Birthright
Birthright has appeared in the basement Defeat ??? as Jacob & Esau. 191
Red Stew
Red Stew
Red Stew has appeared in the basement Defeat Satan as Jacob & Esau. 192
Meat Cleaver
Meat Cleaver
Meat Cleaver has appeared in the basement Defeat The Witness as Isaac. 193
Yuck Heart
Yuck Heart
Yuck Heart has appeared in the basement Defeat The Witness as Magdalene. 194
Red Key
Red Key
The Red Key has appeared in the basement Defeat The Witness as Cain. 195
Akeldama
Akeldama
Akeldama has appeared in the basement Defeat The Witness as Judas. 196
Eternal D6
Eternal D6
Eternal D6 has appeared in the basement Defeat The Witness as ???. 197
Bird Cage
Bird Cage
Bird Cage has appeared in the basement Defeat The Witness as Eve. 198
Donkey Jawbone
Donkey Jawbone
A Donkey's Jawbone has appeared in the basement Defeat The Witness as Samson. 199
Devil's Crown
Devil's Crown
Devil's Crown has appeared in the basement Defeat The Witness as Azazel. 200
Tinytoma
Tinytoma
Tinytoma has appeared in the basement Defeat The Witness as Lazarus. 201
'M
'M
(garbled) has appeared in the basement Defeat The Witness as Eden. 202
Lost Soul
Lost Soul
A Lost Soul has appeared in the basement Defeat The Witness as The Lost. 203
Revelation
Revelation
Revelation has appeared in the basement Defeat The Witness as Bethany (currently bugged, cannot be unlocked). 204
Magic Skin
Magic Skin
Magic Skin has appeared in the basement Defeat The Witness as Jacob & Esau. 205
Rune of Kenaz
Rune of Kenaz
The Rune of Kenaz has appeared in the basement Beat Challenge 2x: Scat Man. 206
Rune of Fehu
Rune of Fehu
The Rune of Fehu has appeared in the basement Beat Challenge 3x: Turbo!. 207
Rune of Gebo
Rune of Gebo
The Rune of Gebo has appeared in the basement Beat Challenge 4x: Bloody Mary. 208
Psy Fly
Psy Fly
Psy fly has appeared in the basement Beat Challenge 8x: Isaac's Awakening (currently bugged, cannot be unlocked). 209
Rune of Othala
Rune of Othala
The Rune of Othala has appeared in the basement Beat Challenge 9x: Seeing Double. 210
Member Card
Member Card
Member Card has appeared in the basement Unknown (Likely bugged). 211
Song of the Siren
Song of the Siren
Song of the Siren has appeared in the basement Bomb the skull left by The Siren after death. 212
Old Capacitor
Old Capacitor
Old Capacitor has appeared in the basement Blow up 10 charge machines. 213
Rotten Heart
Rotten Heart
Rotten Heart has appeared in the basement Enter the Corpse for the first time. 214
Mega Mush
Mega Mush
Mega Mush has appeared in the basement Defeat The Witness with every character on Hard mode. 215
Challenge #3x
Challenge #3x
You unlocked Challenge #3x: Turbo! Unlock Cain. 216
Challenge #4x
Challenge #4x
You unlocked Challenge #4x: Bloody Mary Unlock Bethany, It Lives and Blood Bag. 217
Challenge #8x
Challenge #8x
You unlocked Challenge #8x: Isaac's Awakening Defeat The Witness. 218
Challenge #9x
Challenge #9x
You unlocked Challenge #9x: Seeing Double Defeat The Witness. 219
Soul Baby
Soul Baby
You unlocked Soul Baby Defeat Mom's Heart or It Lives as Bethany on Hard Mode. 220
Double Baby
Double Baby
You unlocked Double Baby Defeat Mom's Heart or It Lives as Jacob & Esau on Hard Mode. 221

Sacdag Antibirth Sacdag

Boss Baby Plum Bosses MainPageChallenges Challenges MainPageChapters Chapters Character Characters Book of Virtues Items
Dumpling Monsters Bucket Objects Immortal Heart Pickups Blessed Penny Icon Trinkets MainPageAchievements Unlockables
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