The Binding of Isaac: Antibirth Wiki
The Binding of Isaac: Antibirth Wiki

The Binding of Isaac: Rebirth

Transformation Appearance Transformation effect Item Icon Item effect Recharge
Beelzebub Transformation Beelzebub appearance.png
  • Flight.
  • Converts small enemy flies into Blue Flies.
???'s Only FriendCollectible Blue Baby's Only Friend icon.pngSummons a big attack fly that can be controlled with the shooting direction-keys.
BBFCollectible BBF icon.pngSpawns a familiar that flies around the room in a manner similar to the Boom Fly and explodes on contact with an enemy. Respawns after ten seconds.
Best BudCollectible Best Bud icon.pngWhen hit, summons a white attack fly similar to Distant Admiration for the current room.
Big FanCollectible Big Fan icon.pngSpawns a large orbital familiar that blocks enemy projectiles and deals slight contact damage to enemies.
Distant AdmirationCollectible Distant Admiration icon.pngA red attack fly circles further out than the Halo Of Flies/Pretty Flies, but closer than Forever Alone. Deals more damage than Forever Alone.
Forever AloneCollectible Forever Alone icon.pngSpawns a blue attack fly that orbits a long distance from Isaac.
Halo Of Flies45x45pxSpawns two pretty fly familiars that block enemy shots and deal contact damage to enemies.
Hive MindCollectible Hive Mind icon.pngIncreases the size of Blue Spiders and Blue Flies and doubles the amount of damage they deal.
SkatoleCollectible Skatole icon.pngAll types of fly except Boom Fly and Red Boom Fly become passive and slowly move towards Isaac. Does not prevent contact damage.
Smart FlyCollectible Smart Fly icon.pngAfter Isaac takes damage, this fly will deal continuous touch damage to whatever enemy caused the damage until it is dead. The fly will then systematically attack 1 enemy at a time until the room is cleared.
The MulliganCollectible The Mulligan icon.pngTears have a 1/6 chance of spawning allied blue flies when they hit an enemy.
InfestationCollectible Infestation icon.png1-3 Blue Flies randomly spawn every time Isaac gets hit.
Friend ZoneCollectible Friend Zone icon.pngA white orbiting fly which deals 3 contact damage per tick to enemies. This familiar orbits Isaac at a middle length distance somewhere between Distant Admiration and Forever Alone.
Lost FlyCollectible Lost Fly icon.pngA familiar fly that moves in a straight line and attaches itself to the first obstacle or wall it comes into contact with in each room. If any enemies walk into its path, it will deal 7 contact damage per tick. If the obstacle it is attached to is destroyed then it will continue rolling in the direction it was previously travelling until it meets another wall or obstacle.
Papa FlyCollectible Papa Fly icon.pngA blue fly familiar follows Isaac's movements on a 3 second delay. Papa Fly will fire tears at nearby enemies.
Obsessed FanCollectible Obsessed Fan icon.pngA purple fly familiar that follows Isaac's movements on a 3 second delay and deals contact damage to enemies.
Guppy! Transformation Guppy appearance.png
  • Flight.
  • Spawns a Blue Fly each time a tear hits an enemy.
Guppy's HeadCollectible Guppy's Head icon.pngSpawns 2-4 Blue Flies to damage enemies.1
Guppy's PawCollectible Guppy's Paw icon.pngRemoves one Heart Container in exchange for gaining 3 Soul Hearts.0
Dead CatCollectible Dead Cat icon.pngSets the amount of red heart containers to 1, but gives Isaac 9 extra lives. After dying, Isaac is teleported to the last safe room. New heart containers can be obtained after picking up this item, but after each death, the number of heart containers is set to 1 again.
Guppy's CollarCollectible Guppy's Collar icon.pngPermanent 50% chance to respawn with 1/2 heart after death.
Guppy's TailCollectible Guppy's Tail icon.pngIncreases chance of finding gold chests and normal chests, but reduces chance of finding pickups.
Guppy's Hair BallCollectible Guppy's Hair Ball icon.pngLoosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies.

The Binding of Isaac: Afterbirth

Transformation Appearance Transformation effect Item Icon Item effect Recharge
Bob 100x100px
  • Isaac gains a green trail of poisonous creep.
Bob's Rotten HeadCollectible Bob's Rotten Head icon.pngUpon use, Isaac holds a poison bomb which can be thrown towards any of the four cardinal points and explodes on impact.3
Bob's BrainCollectible Bob's Brain icon.pngSpawns a familiar that charges forward when shooting tears, explodes upon contact with an enemy and poisons them. Respawns after few seconds.
Bob's CurseCollectible Bob's Curse icon.pngGives 5 bombs and grants all bombs poison effect.
IpecacCollectible Ipecac icon.pngReplaces tears with explosive and poisoning projectiles fired in an arc from the mouth.
Conjoined 100x100px
  • When attacking, the tumor faces shoot tears diagonally outwards, similar to the effect of The Wiz.
  • -0.3 damage.
  • Slightly decreases tears.
Brother BobbyCollectible Brother Bobby icon.pngFollows Isaac around shooting normal tears.
Harlequin BabyCollectible Harlequin Baby icon.pngSpawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
Headless BabyCollectible Headless Baby icon.pngFamiliar that follows Isaac, leaving blood creep on the ground.
Little StevenCollectible Little Steven icon.pngSpawns a familiar that follows Isaac around and fires homing tears.
Mongo BabyCollectible Mongo Baby icon.pngSummons a familiar that copies the tears of Isaac's other familiars.
Rotten BabyCollectible Rotten Baby icon.pngA familiar that spawns Blue Flies.
Sister MaggyCollectible Sister Maggy icon.pngA Familiar that follows Isaac around shooting blood tears.
Fun Guy 100x100px
  • +1 heart container.
God's FleshCollectible God's Flesh icon.pngTears now have a random chance to apply a shrinking effect, causing enemies to shrink in size and also run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.
Mini MushCollectible Mini Mush icon.pngIncreases Speed and Shot Height and decreases Isaac's size, but lowers Range.
Magic MushroomCollectible Magic Mushroom icon.pngIncreases all stats and enlargens Isaac
Odd Mushroom (Thin)Collectible Odd Mushroom (Thin) icon.pngIncreases Tears and Speed while reducing Damage.
Odd Mushroom (Large)Collectible Odd Mushroom (Large) icon.pngGrants an empty heart container. Increases damage, range and shot height while reducing speed.
1up!45x45pxGives an extra life. Upon death, you will respawn in the previous room with full health and lose the 1up!.
Blue CapCollectible Blue Cap icon.pngGrants 1 heart container and increases tears, but decreases shot speed.
Leviathan 100x100px
  • Flight.
  • +2 Black Hearts.
The NailCollectible The Nail icon.pngAdds one Soul Heart and allows the breaking of Rocks and damaging enemies by simply walking over them. Increases Damage and decreases Speed. All effects except for the Soul Heart wear off upon leaving the room.6
The MarkCollectible The Mark icon.pngIncreases Damage and Speed, plus adds one Soul Heart.
The PactCollectible The Pact icon.pngIncreases damage by 0.5, tears by 0.7 and grants two soul hearts upon pickup.
PentagramCollectible Pentagram icon.pngIncreases Damage and increases chances of the Devil Room appearing.
Spirit Of The Night45x45pxGrants spectral tears and flight.
Maw Of The Void45x45px+1.0 Damage Up. After continuously firing tears for 3 seconds, a red cross appears on Isaac's head that, upon releasing the fire button, creates a black ring which deals a lot of damage to any enemies inside it. The ring rapidly deals damage equal to Isaac's tear damage to any enemies in contact with it.
AbaddonCollectible Abaddon icon.pngIncreases damage and speed, removes all red heart containers, grants six black hearts, and adds a chance to shoot fear tears.
BrimstoneCollectible Brimstone icon.pngTears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.
Oh Crap 100x100px
  • Whenever a pile of poop is destroyed, health is replenished by half a heart.
Flush!Collectible Flush! icon.pngChanges all enemies in the room into poop. Does not work on all enemies (Knights and bosses are immune). Instantly kills Dingle, Dangle, and Brownie.6
The PoopCollectible The Poop icon.pngSpawns a pile of poop where the character is standing and knocks nearby monsters back. May yield pickups like regular poop.1
E ColiCollectible E Coli icon.pngGives "Turdy Touch" Effect. Enemies that touch Isaac are changed into Poop.
Seraphim 100x100px
  • Flight.
  • +3 Soul Hearts.
The BibleCollectible The Bible icon.pngUpon activation, Isaac gains Flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan.6
Dead DoveCollectible Dead Dove icon.pngGrants spectral tears and flight.
Guardian AngelCollectible Guardian Angel icon.pngSpawns an orbital familiar that blocks enemy projectiles, deals contact damage to enemies and increases the speed of all orbital familiars.
Holy GrailCollectible Holy Grail icon.pngGrants flight and one heart container.
Holy MantleCollectible Holy Mantle icon.pngAutomatically negates first taken damage in every room.
MitreCollectible Mitre icon.pngGrants a chance of converting any red hearts pickups into soul hearts instead.
RosaryCollectible Rosary icon.pngAdds 3 Soul Hearts and increases the chance for The Bible to appear in any item pool.
Sworn ProtectorCollectible Sworn Protector icon.pngAn orbital angel which does 7 contact damage per tick and blocks enemy shots. When it blocks a shot, it has a very small chance to drop an eternal heart.
The HaloCollectible The Halo icon.pngGrants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height.
Spun 100x100px
  • +2 damage.
  • +0.15 speed.
  • Spawns a random pill upon transformation.
Experimental TreatmentCollectible Experimental Treatment icon.pngRandomly increases and decreases some of the character's stats. There will always be at least one stat increase and one decrease and the same stats can be increased/decreased multiple times.
Growth HormonesCollectible Growth Hormones icon.pngIncreases damage by 1 and speed by 0.4.
Roid RageCollectible Roid Rage icon.pngIncreases speed by 0.6, range by 5.25, and tear height by 0.5.
Speed BallCollectible Speed Ball icon.pngIncreases speed by 0.3 and shot speed by 20%.
SynthoilCollectible Synthoil icon.pngIncreases damage by 1, range by 5.25, and tear height by 0.5.
The VirusCollectible The Virus icon.pngInflicts poison to enemies who make contact with Isaac. Speed down.
Yes, Mother? 100x100px
  • Isaac gains a stationary knife that trails directly behind him. It synergizes like Mom's Knife would.
Mom's Bottle Of Pills45x45pxGives Isaac a random Pill, and will cause him to drop any held Q-slot item (If any). The player will only receive six different pill types in one playthrough.6
Mom's BraCollectible Mom's Bra icon.pngUpon use, petrifies all enemies in the current room for approximately 4 seconds.3
Mom's PadCollectible Mom's Pad icon.pngUpon use, inflicts fear to all enemies in the room for 5 seconds.3
Mom's WigCollectible Mom's Wig icon.pngAdds a chance to spawn Blue Spiders when firing tears. Restores 1 red heart.
Mom's EyeCollectible Mom's Eye icon.pngAllows Isaac to fire tears from the back of his head.
Mom's PurseCollectible Mom's Purse icon.pngAllows Isaac to hold 1 additional trinket.
Mom's ContactsCollectible Mom's Contacts icon.pngAdds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. Range up.
Mom's KnifeCollectible Mom's Knife icon.pngIsaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
Mom's HeelsCollectible Mom's Heels icon.pngIncreases range.
Mom's EyeshadowCollectible Mom's Eyeshadow icon.pngTears have a chance to charm enemies.
Mom's PerfumeCollectible Mom's Perfume icon.pngAdds a chance to shoot fear tears and increases Tears by 0.16.
Mom's KeyCollectible Mom's Key icon.pngSpawns 2 keys. Generates additional pickups from chests.
Mom's LipstickCollectible Mom's Lipstick icon.pngIncreases range and shot height.
Mom's UnderwearCollectible Mom's Underwear icon.pngIncreases range.
Mom's Coin PurseCollectible Mom's Coin Purse icon.pngSpawns 4 random Pills around Isaac.
Mom's PearlsCollectible Mom's Pearls icon.png+1.25 Range Up. +0.5 Tear Height. +1 Luck Up.
Super Bum 100x100px
  • Replaces Bum Friend, Dark Bum, and Key Bum for Super Bum.
    He collects any of the other beggars' pickups, and offers twice the rewards.
Bum FriendCollectible Bum Friend icon.pngA portable Beggar who follows Isaac, picks up coins for himself, and occasionally drops a Pickup after collecting a coin. Does not spawn Collectibles.
Dark BumCollectible Dark Bum icon.pngSpawns a familiar that follows Isaac around and collects Red Hearts. For every one-and-a-half red hearts collected, Dark Bum will generate one Soul Heart, one hostile Spider or one friendly Blue Spider.
Key BumCollectible Key Bum icon.pngSpawns a portable Key Master that follows Isaac and collects keys, giving random chests in return.
1: Image depicts the familiar. This transformation does not alter Isaac's appearance.