For changes to Rebirth items, see Changes.

Items are an integral part of game-play in The Binding of Isaac: Rebirth. They modify Isaac's Attributes, grant or modify Tear Effects, and much more. Antibirth adds over 90 new items.

Active Items

Name Icon Description Recharge
Alabaster Box Alabaster Box Icon.pngGains charges through soul, black, and white hearts. After 6 full hearts are absorbed, it will spawn varying amounts of consumables and items from the Angel room pool.One time use, 12 charges to use
Black Mushroom Black Mushroom Icon.pngReduces tear delay but distorts the screen for a length of time. Can be used multiple times to stack the effect. Tear delay is reset on changing rooms; however, the distortion persists.1 second
Book Of Despair Book Of Despair Icon.pngHalves tear delay for the current room.3
Book Of Virtues Book Of Virtues Icon.pngSummons a temporary flame familiar that fires spectral tears, deal contact damage to enemies and blocks enemy shots. Flames are consumed after taking a certain amount of damage or touching enemies. A maximum of 16 flames can be active at once: one inner ring of eight and an outer ring of eight.2
Bowl of Tears Bowl of Tears Icon.pngFires a cluster of tears. Each tear shot by Isaac increases item charge by one.6
D12 D12 Antibirth Icon.pngRe-rolls all rocks in the current room into other random objects, such as bomb rocks, metal blocks, TNT, or poop.3
Damocles Damocles Icon.pngSpawns a sword above Isaac's head, which doubles all item pedestals while it remains. After Isaac takes damage, the sword can randomly fall at any point, instantly killing him.One time use
Eraser Eraser Icon.pngThrows an eraser which instantly kills the first enemy it hits, also killing all other copies in the room. If it hits a non-boss, prevents them from spawning for the rest of the run.One time use
Eternal D6 Eternal D6 Icon.pngRerolls all items in the room. Each item has a chance to disappear instead.3
Fortune Cookie Fortune Cookie Icon.pngDisplays a random fortune, and has a chance to drop a soul heart, card, rune or trinket.2
Free Lemonade Free Lemonade Icon.pngCreates a large puddle of lemonade that damages enemies.4
Magic Skin Magic Skin Icon.pngGenerates one item from the current room's item pool and gives Isaac a broken heart, which permanently decreases the maximum health limit.6
Meat Cleaver Meat Cleaver Icon.pngSplits all enemies in a room into 2 smaller versions of themselves with lower health.2
Mega Mush Mega Mush Icon.pngGigantifies Isaac, increasing damage and range while lowering tears, granting invulnerability, and allowing Isaac to crush enemies and obstacles he walks on. The effect persists between rooms.12
Mom's Bracelet Mom's Bracelet Icon.pngAllows Isaac to grab obstacles and throw them, damaging enemies.1 second
R Key R Key Icon.pngUpon use, restarts the game to the first floor, keeping all previously collected items. Game timer does not restart. Allows angels rooms to be found even if the previous run included devil deals.One time use
Red Key Red Key Icon.pngCreates a red colored room on the map near Isaac's current position. The room can be anything from a regular encounter room to a Devil Room.3
The Scooper The Scooper Icon.pngSummons a Peeper familiar for the current room, which leaves a trail of red creep.3
Sharp Key Sharp Key Icon.pngAllows Isaac to consume keys and fire them at enemies. Adds 5 keys.0
Stitches Stitches Icon.pngSpawns a familiar that flies diagonally across the room, switching direction upon hitting walls. Activating the item swaps the positions of Isaac and Stitches.3 seconds
Sulfur Sulfur Icon.pngGrants Brimstone for the current room.3
Voodoo Pin Voodoo Pin Icon.pngHurts Isaac without actually damaging him, activating any items that would trigger upon taking damage.2
Yuck Heart Yuck Heart Icon.pngUpon use, grants a rotten heart.4

Passive Collectibles

Name Icon Description
120 Volt 120 Volt Icon.pngWhenever an enemy is shot, it will zap other enemies near them, dealing damage.
2Spooky 2Spooky Icon.pngEnemies near Isaac will be inflicted with Fear, causing them to flee from him.
A Bar Of Soap A Bar Of Soap Icon.pngIncreases tears and shot speed.
Act Of Contrition Act Of Contrition Icon.pngGrants an Immortal Heart and increases tears. Angel Rooms can appear even if a Devil deal has been taken.
Akeldama Akeldama Icon.pngWhile in an uncleared room, Isaac forms trails of bloody tears that drag behind him, bursting and dealing damage upon contact with enemies.
Almond Milk Almond Milk Icon.pngUpgrades fire rate immensely but significantly decreases damage, and tears are given random worm effects.
Battery Pack Battery Pack Icon.pngRecharges Isaac's currently held active item and drops 2-4 batteries.
Bird Cage Bird Cage Icon.pngThe first time Isaac takes damage in a room, the familiar leaps on an enemy, dealing damage and releasing a rock wave. For the rest of the room, it chases enemies similar to Dead Bird.
Bird's Eye Bird's Eye Icon.pngAdds a chance to shoot a fire instead of a tear, which pierces and can block enemy shots, diminishing in size as it does.
Birthright Birthright Icon.pngHas a different effect for each character.
Blood Bombs Blood Bombs Icon.pngGrants 1 heart container. Bombs create puddles of damaging red creep upon exploding. If Isaac has no bombs, bombs can be placed at the cost of half a heart.
Blood Oath Blood Oath Icon.pngStabs Isaac at the beginning of each floor, draining all but half a heart of his red hearts. Increases damage and speed for the floor based on the amount drained.
Boiled Baby Boiled Baby Icon.pngGrants a familiar similar to a Boil that periodically fires bursts of bullets.
Booster Pack Booster Pack Icon.pngSpawns 3 tarot cards.
Bot Fly Bot Fly Icon.pngGrants a familiar that fires shielded tears at incoming bullets.
Consolation Prize Consolation Prize Icon.pngIncreases Isaac's lowest stat and grants either 3 coins, 1 bomb, or 1 key depending on what Isaac has the least of.
Dirty Mind Dirty Mind Icon.pngDestroying poop spawns friendly Dips that follow Isaac and damage enemies. Destroying different types of poop spawns different Dips with special effects.
Donkey Jawbone Donkey Jawbone Icon.pngIsaac does a spin attack that damages nearby enemies whenever he takes damage. Killed enemies have a chance to drop a red heart.
Enigma Bombs Enigma Bombs Icon.pngGrants 5 bombs. Bombs explode with a random bomb effect.
Evil Charm Evil Charm Icon.pngGrants +3 luck.
Eye Drops Eye Drops Icon.pngLowers the tear delay in Isaac's left eye, causing his eyes to fire at different rates.
Eye Of The Occult Eye Of The Occult Icon.pngIncreases damage. Tears can be controlled mid-flight using the fire keys.
Eye Sore Eye Sore Icon.pngFrequently fire tears in random directions in addition to regular tears. Can fire up to three extra tears.
Freezer Baby Freezer Baby Icon.pngGrants a familiar that fires shots that freeze enemies. Frozen enemies explode into ice shards when touched.
Immaculate Heart Immaculate Heart Icon.pngAdds a heart container and increases damage. Isaac fires spectral orbiting tears alongside normal tears.
The Intruder The Intruder Icon.pngA familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room.
It Hurts It Hurts Icon.pngTaking damage causes Isaac to release a ring of bloody tears and increases fire rate for current room.
Jacob's Ladder Jacob's Ladder Icon.pngGenerates a ladder in the starting room of all future floors, which leads to a special Angel Room.
Knife Piece 1 Knife Piece 1 Icon.pngHas no effect on its own. Picking up all three pieces grants a knife familiar that damages enemies and grants access to the Corpse.
Knife Piece 2 Knife Piece 2 Icon.pngHas no effect on its own. Picking up all three pieces grants a knife familiar that damages enemies and grants access to the Corpse.
Knife Piece 3 Knife Piece 3 Icon.pngHas no effect on its own. Picking up all three pieces grants a knife familiar that damages enemies and grants access to the Corpse.
Knockout Drops Knockout Drops Icon.pngAdds a chance to fire fist tears, which have massive knockback and briefly stun enemies.
Lil' Dumpy Lil' Dumpy Icon.pngGrants a familiar that loosely follows Isaac. It farts when hit by enemy attacks, poisoning or stunning enemies and sending it bouncing away.
Lodestone Lodestone Icon.pngAdds a chance to fire magnetizing tears. Magnetized enemies attract other enemies, Isaac's tears, and enemy shots including their own.
Lost Soul Lost Soul Icon.pngSpawns a Lost familiar that follows Isaac. It dies if hit by an enemy, regenerating on the next floor. If it survives an entire floor, it grants a random reward.
Luna Luna Icon.pngAdds one extra Secret Room and one Super Secret Room on each floor.
Mars Mars Icon.pngCharge in a direction by double-tapping the movement key, becoming invulnerable and damaging enemies. There's a short cooldown before Isaac can dash again.
Member Card Member Card Icon.pngOpens a trapdoor with a ladder in every shop. The trapdoor leads to a special shop room, which sells multiple items or pickups for random prices. Sold collectibles don't have to be from the Shop pool.
Menorah Menorah Icon.pngSpawns a familiar that grants an extra tear per shot for each lit candle. A candle is lit each time Isaac takes damage, up to 7. Being hit again will reset the menorah and release blue flames.
Mercurius Mercurius Icon.pngDoors stay open after entering a room, even with enemies in it, allowing Isaac to leave any time. Increases speed.
Monstrance Monstrance Icon.pngIsaac emits an aura that damages nearby enemies.
Mucormycosis Mucormycosis Icon.pngEnemies release a cloud of gas upon death that damages and poisons other enemies.
Oculus Rift Oculus Rift Icon.pngAdds a chance to fire tears that summon rifts wherever they land. Rifts attract enemies, enemy shots, Isaac's tears, and pickups. They also deal contact damage to enemies caught in them.
Orphan Socks Orphan Socks Icon.pngGrants +0.15 Speed and two Soul Hearts. Isaac can walk on harmful floor effects without taking damage.
Paschal Candle Paschal Candle Icon.pngIncreases tears for each room completed without taking damage. Resets on taking damage.
Playdoh Cookie Playdoh Cookie Icon.pngGrants multicolored tears, which can be normal, petrifying, homing, poisoning, or fear-inducing based on their color.
Pluto Pluto Icon.pngSignificantly shrinks Isaac, allowing him to squeeze between objects and making some enemy shots pass over him. Increases tears and speed, but decreases range.
Psy Fly Psy Fly Icon.pngCatches enemy shots and flings them back at enemies as homing tears.
Red Stew Red Stew Icon.pngRestores all red heart containers. Grants an enormous damage boost that wears off over time.
Revelation Revelation Icon.pngAdds 2 Immortal Hearts, grants flight, gives tears a Brain Worm-like homing effect, decreases range and increases shot speed.
Rock Bottom Rock Bottom Icon.pngLowers all stats to their base value. Prevents stats from being lowered the rest of the run.
Rocket In A Jar Rocket In A Jar Icon.pngGrants 5 bombs. Bombs become rockets that fly in the direction Isaac is currently looking.
Rotten Tomato Rotten Tomato Icon.pngTears have a chance to mark enemies. Marked enemies will be attacked by other enemies.
Saturnus Saturnus Icon.pngIsaac is surrounded by an aura which has a chance to absorb incoming enemy tears. It begins with 7 orbiting tears when entering a new room.
Sausage Sausage Icon.pngAll stats up.
Schoolbag Schoolbag Icon.pngGrants an extra active item slot.
Sol Sol Icon.pngReveals the location of the Boss room. Upon defeating a boss, activates XIX - The Sun, fully recharges Isaac's active item, and grants bonus damage and luck for the rest of the floor.
Spirit Sword Spirit Sword Icon.pngInstead of tears, Isaac swings a sword. Charging does a spin attack and fires a projectile, and a projectile is fired with every swing if Isaac has no empty red hearts.
Stone Bombs Stone Bombs Icon.pngGrants 5 bombs. Bombs release rock waves in the cardinal directions, which can damage enemies, destroy obstacles, and damage Isaac.
Terra Terra Icon.pngIsaac's tears become rocks that have increased knockback and deal variable damage, and have a high chance to destroy obstacles.
Tinytoma Tinytoma Icon.pngA large familiar slowly orbits Isaac. Upon taking enough damage, it splits into two smaller orbitals. If they take enough damage, they burst into blue spiders and the large orbital respawns.
Uranus Uranus Icon.pngIsaac shoots ice tears, which freeze enemies they kill. Frozen enemies slide away and explode into ice shards when touched.
Venus Venus Icon.pngAdds one Red heart. Enemies near Isaac are Charmed, causing them to attack other enemies.
Voodoo Head Voodoo Head Icon.pngAdditional curse rooms can spawn each floor.

Sacdag.png Antibirth Sacdag.png

Boss Baby Plum.png Bosses MainPageChallenges.png Challenges MainPageChapters.png Chapters Character.png Characters Book of Virtues.png Items
Dumpling.png Monsters Bucket.png Objects Immortal Heart.png Pickups Blessed Penny Icon.png Trinkets MainPageAchievements.png Unlockables
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