|: no : yes|
Isaac's Awakening is a new challenge unlocked by beating The Witness for the first time. The challenge tasks you with making it through the Antibirth chapters with the specific setup the game gives you.
You must beat "Mother" in the Corpse in order to unlock the Spirit Sword.
- Isaac's Awakening is a reference to The Legend of Zelda: Link's Awakening, emphasized by many of the items the challenge starts you off with:
|1x.||Coming soon||2x.||Scat Man||3x.||Turbo!||4x.||Bloody Mary||5x.||Coming soon|
|6x.||Coming soon||7x.||Coming soon||8x.||Isaac's Awakening||9x.||Seeing Double||10x.||Coming soon|