The Binding of Isaac: Antibirth Wiki
The Binding of Isaac: Antibirth Wiki
Isaac's Awakening
Challenge number
Character Isaac appearance.png

Health: HUD heart red full.pngHUD heart red full.pngHUD heart red full.png

Starting Items
Trinity Shield
Mom's Bracelet
Spirit Sword
Available rooms
Item Pool Treasure Room.png: no          Item Pool Shop.png: yes
Boss The Witness.png
Psy Fly

Isaac's Awakening is a new challenge unlocked by beating The Witness for the first time. The challenge tasks you with making it through the Antibirth chapters with the specific setup the game gives you.

At the current date, it does unlock nothing and will remain un-crossed on the challenge list, due to a bug.


  • Isaac's Awakening is a reference to The Legend of Zelda: Link's Awakening, emphasized by many of the items the challenge starts you off with:

MainPageChallenges.png Challenges MainPageChallenges.png

1x. Coming soon 2x. Scat Man 3x. Turbo! 4x. Bloody Mary 5x. Coming soon
6x. Coming soon 7x. Coming soon 8x. Isaac's Awakening 9x. Seeing Double 10x. Coming soon