Isaac's Awakening
Challenge number
Character Isaac appearance.png

Health: HUD heart red full.png HUD heart red full.png HUD heart red full.png

Starting Items
Trinity Shield
Mom's Bracelet
Spirit Sword
Available rooms
Item Pool Treasure Room.png : no           Item Pool Shop.png : yes
Boss The Witness.png
Psy Fly

Isaac's Awakening is a new challenge unlocked by beating The Witness for the first time. The challenge tasks you with making it all the way through the Antibirth chapters with the specific setup the game gives you.


  • Isaac's Awakening is a reference to The Legend of Zelda: Link's Awakening, emphasized by many of the items the challenge starts you off with:
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