Chapters

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Chapters are sets of floors which contain similar enemies, themes, bosses, and difficulties. Chapters are divided into two floors.

Antibirth introduces four new chapters, which come with higher risk in exchange for higher reward. After unlocking "A Secret Exit", locked doors to the new chapters will appear upon defeating bosses in the first three chapters.

Chapter 1

Downpour.png
Downpour

Chapter 2

Mines.png
Mines

Chapter 3

Mausoleum.png
Mausoleum

Chapter 4

Corpse.png
Corpse
SmallIsaac.pngChaptersSmallIsaac.png
Chapter 1 Chapter 2 Chapter 3 Chapter 4
Stage downpour.png
Downpour
Stage mines.png
Mines
Stage mausoleum.png
Mausoleum
Stage corpse.png
Corpse

Sacdag.png Antibirth Sacdag.png

Boss Baby Plum.png Bosses MainPageChallenges.png Challenges MainPageChapters.png Chapters Character.png Characters Book of Virtues.png Items
Dumpling.png Monsters Bucket.png Objects Immortal Heart.png Pickups Blessed Penny Icon.png Trinkets MainPageAchievements.png Unlockables