Bosses are strong monsters found in boss rooms at the end of a floor. The boss at the end of the floor must be defeated in order to advance to the next floor. The boss for a particular floor is chosen from the pool of bosses for the environment of the floor. Upon defeat, most bosses will drop an item from the boss item pool.
Antibirth adds 16 new bosses and a few variants on existing bosses.
Chapter 1
Normal Chapters
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| Baby Plum |
Downpour
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| Wormwood | Beelzeblub | The Rainmaker | The Haunt |
Chapter 2
Mines
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| Tuff Twins | Great Gideon | Hornfel |
Chapter 3
Floor 1
Normal Chapters
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| The Pile | Reap Creep |
Mausoleum
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| The Heretic | The Visage | The Siren |
Floor 2
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| Mausoleum Mom |
Chapter 4
Corpse
Floor 1
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| The Scourge | Rotgut | Chimera |
Floor 2
| The Witness |
 Bosses
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 Challenges
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 Chapters
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 Characters
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 Items
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 Monsters
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 Objects
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 Pickups
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 Trinkets
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 Unlockables
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