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Pickup Rules Card icon.png This article is about the changes of "The Binding of Isaac: Antibirth". For the main page, see Bosses.

Bosses are strong monsters found in boss rooms at the end of a floor. The boss at the end of the floor must be defeated to advance to the next floor. The boss for a particular floor is chosen from the pool of bosses for the environment of the floor. Upon defeat, most bosses will drop an item from the boss item pool.

Antibirth adds 16 new bosses and a few variants on existing bosses.

Normal Chapters[edit | edit source]

Chapter 1[edit | edit source]

Boss Baby Plum.png
Baby Plum

Chapter 3[edit | edit source]

Boss The Pile.png Boss Reap Creep.png
The Pile Reap Creep

Downpour[edit | edit source]

Boss Wormwood.png Boss Beelzeblub.png
Boss The Rainmaker.png
Boss The Haunt.png
Wormwood Beelzeblub The Rainmaker The Haunt

Mines[edit | edit source]

Boss Tuff Twins.png
Boss Great Gideon.png
Boss Hornfel.png
Boss Reap Creep.png
Tuff Twins Great Gideon Hornfel Reap Creep

Mausoleum[edit | edit source]

Floor 1[edit source]

Boss The Heretic.png
Boss The Visage.png
Boss The Siren.png
Boss The Pile.png
The Heretic The Visage The Siren The Pile

Floor 2[edit source]

Boss Mom.png
Mausoleum Mom

Corpse[edit | edit source]

Floor 1[edit source]

Boss The Scourge.png
Boss Rotgut.png
Boss Chimera.png
The Scourge Rotgut Chimera

Floor 2[edit source]

Boss The Witness.png
The Witness

Universal[edit | edit source]

These bosses have a chance of replacing a boss from an environment pool, including Antibirth floors.

Boss The Fallen.png
The Fallen

Bosses Boss Baby Plum.png
Rebirth Chapters Baby PlumReap CreepThe Pile
Downpour BeelzeblubThe RainmakerWormwood
Mines Great GideonHornfelTuff Twins
Mausoleum Mausoleum MomThe HereticThe SirenThe Visage
Corpse ChimeraRotgutThe ScourgeThe Witness

Sacdag.png Antibirth Sacdag.png

Boss Baby Plum.png Bosses MainPageChallenges.png Challenges MainPageChapters.png Chapters Character.png Characters Book of Virtues.png Items
Dumpling.png Monsters Bucket.png Objects Immortal Heart.png Pickups Blessed Penny Icon.png Trinkets MainPageAchievements.png Unlockables