Pickups

''For changes to Rebirth pickups, see Changes. For pickups which are in the game but unobtainable, see Pickups (Unused)''

Antibirth adds a few new types of pickups.

Immortal Heart


Immortal Hearts are white hearts which append to the end of the health bar like soul hearts.

Immortal Hearts always take two hits to be fully depleted and will regenerate from half to full upon clearing a room.

Immortal Hearts replace Eternal Hearts with a 50% chance and do not spawn in any other way, except for one room in the Corpse.

Rotten Heart


Rotten Hearts are infested red hearts that fill up a full heart container. If a Rotten Heart is picked up at full health, it will replace the rightmost red heart.

For each Rotten Heart possessed upon clearing a room, two blue flies will spawn. You cannot have half a Rotten Heart; they are always depleted in one hit.

Depleting a Rotten Heart will not count against Devil Deal Chance when it's the rightmost red heart.

Rotten Hearts are unlocked by entering the Corpse for the first time.

Pills
Three new pill effects were introduced in Antibirth.

Runes
Multiple new runes were added in Antibirth. When on the ground, these runes look like:

Trivia

 * The Rune of Fehu is similar to the Hermit? card introduced in Repentance.
 * Shot Speed Up and Shot Speed Down were part of the Community Remix mod.
 * Immortal hearts are one of the major additions to Antibirth that were not ported into Repentance.