Isaac's Awakening

Isaac's Awakening is a new challenge unlocked by beating The Witness for the first time. The challenge tasks you with making it through the Antibirth chapters with the specific setup the game gives you.

At the current date, it does unlock nothing and will remain un-crossed on the challenge list, due to a bug.

Trivia

 * Isaac's Awakening is a reference to The Legend of Zelda: Link's Awakening, emphasized by many of the items the challenge starts you off with:
 * The Spirit Sword represents the Level 2 Sword.
 * The Trinity Shield represents the Shield item.
 * Mom's Bracelet represents the Power Bracelet.